After three days post-infection with Ebola virus, 100% of rhesus monkeys survived after being given antiviral treatment. In addition, the monkeys exhibited a reduction in viral load as well as a decrease in the physical signs of the disease. This research was conducted by the US Army Medical Research Institute of Infectious Diseases.
The initial compound being worked with was a precursor to GS-5734, which is a small antiviral agent. GS-5734 is a novel prodrug which the Ebola virus by blocking the virus’s ability to replicate it’s genetic material.
The thing I found most interesting about this discovery is that GS-5734 use is favorable in humans because it can be made using a well-controlled chemical procedure and can be produced in mass quantities. I think that this research should be further studied to see how this antiviral can be used to cure the Ebola virus in humans. It will be interesting to see how soon this can be implemented. My question for the class is: How do you think we should go about testing this antiviral in human subjects?
Travis K. Warren, Robert Jordan, Michael K. Lo, Adrian S. Ray, Richard L. Mackman, Veronica Soloveva, Dustin Siegel, Michel Perron, Roy Bannister, Hon C. Hui, Nate Larson, Robert Strickley, Jay Wells, Kelly S. Stuthman, Sean A. Van Tongeren, Nicole L. Garza, Ginger Donnelly, Amy C. Shurtleff, Cary J. Retterer, Dima Gharaibeh, Rouzbeh Zamani, Tara Kenny, Brett P. Eaton, Elizabeth Grimes, Lisa S. Welch, Laura Gomba, Catherine L. Wilhelmsen, Donald K. Nichols, Jonathan E. Nuss, Elyse R. Nagle, Jeffrey R. Kugelman, Gustavo Palacios, Edward Doerffler, Sean Neville, Ernest Carra, Michael O. Clarke, Lijun Zhang, Willard Lew, Bruce Ross, Queenie Wang, Kwon Chun, Lydia Wolfe, Darius Babusis, Yeojin Park, Kirsten M. Stray, Iva Trancheva, Joy Y. Feng, Ona Barauskas, Yili Xu, Pamela Wong, Molly R. Braun, Mike Flint, Laura K. McMullan, Shan-Shan Chen, Rachel Fearns, Swami Swaminathan, Douglas L. Mayers, Christina F. Spiropoulou, William A. Lee, Stuart T. Nichol, Tomas Cihlar, Sina Bavari. Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys. Nature, 2016; DOI:1038/nature17180