Is Trimethoprim-Sulfamethoxazole a Valid Alternative in the Management of Infections in Children in the Era of Community-Acquired Methicillin-Resistant Staphylococcus aureus? A Comprehensive Systematic Review

One of the growing problems in he practice of pharmacy is the increasing emergence of strains of bacteria immune to the antibiotics that are currently on the market. Through over-prescribing, non-adherence, and other contributing factors, the need for new antibiotics is as high as it was when penicillin was first discovered. But as we all know, a drug doesn’t hit the market immediately. It can be over 10 years to before a drug is approved so what are we supposed to do in that time? Let the bacteria beat our current antibiotics? Or is there something more we can do to combat antibiotic resistance.

 

Rosanova et. al reviewed the literature to determine if trimethoprim-sulfamethoxazole had been proven to effectively treat Methicillin-Resistant Staphylococcus aureus (MRSA) in children. According to the first consult page on MRSA on clinicalkey, the outpatient treatment of MRSA includes drugs like clindamycin and linezolid for both pediatrics and adults. It also mentions trimethoprim-sulfamethoxazole as a treatment but only in adults. The review done by Rosanova et al found just 4 primary articles that studied trimethoprim-sulfamethoxazole in a randomized controlled study in children and the results were inconclusive.

 

While the findings of this article may not be significant, the fact that it was even written is. This article proves that while we work to discover newer and more effective antibiotics, we must also reevaluate the ones we currently use and find other possible uses for them.

 

Rosanova, M. T., Pompa, L. C., Perez, G., Sberna, N., Serrano-Aguilar, P., & Lede, R. (2016). Is Trimethoprim-Sulfamethoxazole a Valid Alternative in the Management of Infections in Children in the Era of Community-Acquired Methicillin-Resistant Staphylococcus aureus? A Comprehensive Systematic Review. Journal of Pharmacy Technology, 32(2), 81-87. Retrieved February 22, 2016.

 

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