Researchers at The University of Texas MD Anderson Cancer Center have been studying how dietary sugar effects enzymatic signaling of the 12-LOX (12-lipooxygenase) pathway. The researchers found that mice who had sucrose intake similar to those found in Western diets lead to an increased risk of tumor development and metastasis. Specifically, they studied the impact of how sucrose influenced mammary gland tumor development in several mouse models.
This is the first study to investigate the direct effect of sugar consumption and how it relates to the development of breast cancer. The researchers believe that the mechanism by which the sugar effects tumor growth, the 12-LOX pathway, needs to be further studied.
I think this article is very interesting because I had never even thought of dietary sugar levels leading to cancer development. This is important as a pharmacist because we can make recommendations to patients to eat healthier or refer them to a dietician. If this data holds true in humans, it will be another great counseling point to make in order for our patients to eat less unnecessary sugar to improve overall health. My questions for the class are: Have you ever thought that excess dietary sugar could lead to cancer development? And, if the data translated to humans, do you think people would change their diet if they knew this information?
Yan Jiang, Yong Pan, Patrea R. Rhea, Lin Tan, Mihai Gagea, Lorenzo Cohen, Susan M. Fischer, and Peiying Yang. A Sucrose-Enriched Diet Promotes Tumorigenesis in Mammary Gland in Part through the 12-Lipoxygenase Pathway. Cancer Res, January 1, 2016 76:24-29 DOI: 10.1158/0008-5472.CAN-14-3432