Antidepressant medication use and glycaemic control in co-morbid type 2 diabetes and depression

Depression is common in diabetes diagnosed patients and it also causes increased risk of hyperglycemia, morbidity, and mortality. A study was conducted to determine if the use of antidepressant medication is associated with glycemic control in depressed patients with type 2 diabetes.

This study was conducted using electronic medical record registry data of ambulatory primary care visits from 2008 to 2013. Relationship between ADM use (determined by prescription orders) and glycaemic control (determined from measures of glycated hemoglobin/ A1C) were studied. A good glycemic control was defined as AIC < 7.0%.  Good glycemic control was achieved by 50.9% of depressed subjects receiving ADM versus 34.6% of depressed subjects without ADM.

Although this relationship studied does not take into account adherence of medication, it still proves an interesting point; medication taken for a separate indication but relating to the primary disease state may help in patient drug therapy. It is important to not only look at the disease state and what medications are specific for that disease state, but also to view the broad picture. What else is the patient currently diagnosed with? Even if these disease states do not directly relate to the primary disease state, they could serve as clues into figuring out what is best for the patient.

Brieler J., Lustman P., Scherrer J., et al. Antidepressant medication use and glycaemic control in co-morbid type 2 diabetes and depression. Fam. Pract. 2016; 33: 30-6

2 thoughts on “Antidepressant medication use and glycaemic control in co-morbid type 2 diabetes and depression”

  1. I think that this is a very interesting study and I think that your analysis of it is very thoughful. I agree that adherence is a key point that the study maybe didn’t take into consideration. I also agree that other disease states could come into play when considering the outcomes of this study. I would want to know, do we think that glycemic conrol is higher in patients taking ADM because of he medication itself or because their depression is controlled?

  2. This is actually often seen in the pharmacy. There are many physicians who are ‘smart’ about what they prescribe because this medication may actually help with multiple conditions at once. Personally, I think that my pharmacist has pointed out many more errors in medication choice by doctors. Because of this I feel that pharmacists should have a little more say in the selection of medications for patients with multiple conditions. In fact, my preceptor has actually called many physicians to make the suggestion to the physician. Yes, it often is taking the valsartan-HCTZ combo instead of the two pills separately, but if given more opportunity to select medications the indications could be more widely used for benefits. I know I kind of went off on a tangent there but it certainly is good for healthcare providers to look at the ‘full picture’ of a patient’s medical record.

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